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The accurate experimental delineation of the structure of this clinically relevant gene represents an important step in facilitating ongoing drug development efforts.
In general, cannabinoid agonists do not show a great deal of selectivity between CB1 and CB2 binding; however, newly developed synthetic antagonists are now available that allow the experimental delineation of CB1 versus CB2 effects.
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An experimental central composite rotational delineation (CCRD) type design was used to define the aeration conditions and nitrogen load (factors) to be studied.
In any case, such an experimental system allows the delineation of molecular mechanisms important for the contracting muscle fiber that cannot be performed in muscle in vivo.
As a validation, we looked at transcript delineation by experimental evidence.
We propose to combine the computational prediction of alternative splice isoforms with experimental validation for efficient delineation of an accurate set of tissue-specific transcripts.
Implementation of the H-H* experimental paradigm makes possible a delineation of transcriptional changes and neural, endocrine, and immune pathways that are activated in precisely defined stressor contexts.
Due to the suitable in vitro and in vivo stability of the tracer, its rapid and specific activity accumulation in the Daudi xenograft, as well as rapid clearance from the background, PET images resulted in a clear delineation of the experimental tumors in vivo.
This growth pattern contributes sampling irregularities and certain variance in experimental measurements that prohibit absolute delineation of cellular responses to defined experimental conditions [43]; however, in this study we devised a number of measures into our experimental design for the consistent collection of reliable data.
These sites enable targeted experimental validation and thus further delineation of the Crp and PurR regulons in E. coli.
The results of RAMPAGE simulations compare favourably to theoretical and experimental data from various disciplines and allow delineation of the field of gravitationally stable random packing of equal-sized spheres in the 2-D state space of porosity (P) versus mean coordination number (N).
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