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An important advantage of the MACO scheme is the simplicity of the approach that allows the dramatic reduction in the number of experiment trails.
A potential advantage of MACO is that experiment trails are performed in parallel, which dramatically reduces the time required for determining a synergistic cocktail.
A major difference between these search algorithms and MACO is that stochastic search algorithms are sequential search methods (i.e., experiments are performed one by one) while all experiment trails in MACO can be operated in parallel.
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In animal experiments, TRAIL did not cause systemic toxicity (Kagawa et al, 2001).
Following the in vitro experiments, TRAIL expression and its tumoricidal activity were analyzed in nude mice with subcutaneous xenografts of HNSCC.
Experiments, where TRAIL signaling was inhibited by silencing DR5 [24] or by increasing the expression of the decoy receptor DcR2 [25], led to the conclusion that chemosensitivity to 5-fluorouracil, doxorubicin, and etoposide depends on TRAIL receptor signaling.
In these experiments, the TRAIL lentivirus is conditionally activated with the addition of doxycycline, and carries green fluorescent protein to enable the monitoring of gene activation.
These high-resolution stills feature stunningly detailed scenes of abandoned experiment sites and trails made by astronauts' boots and lunar rovers.
These optimum conditions were used to evaluate the trail experiment, and the maximum yield of COD removal was recorded as 98.5%.
To test this concept, we transduced TRAIL-resistant human mesenchymal stem cells (hMSCs) with AdsTRAIL in the upper chamber of a two-chamber transwell experiment and plated TRAIL-sensitive U251HF cells in the lower chamber.
In experiment 2, when trail pheromone is only present on one of the two branches, ants still prefer the less deviating branch, but the preference for the less deviating branch did not increase as the asymmetry increased (Fig. 3a).
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