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The principal concern expressed by the reviewers/editor was the need for evidence beyond the FRET experiment to "shift the balance of conviction" for the model of Insulin/IGF-1 receptor activation we present, and the major suggestions involved simple experiments to do just that.
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The pressure difference is closed to detection limit (peak ∆P ≈ 1.1 atm), and such experiment is difficult to shift the recovery record (cross symbol in Fig. 10) to be with real time data (circle symbol), or be parallel with pressure data.
In another animal experiment, THP was reported to shift from the apical toward the basolateral membrane by induced ischemic injury [ 22].
Since the early years of this century (20th), the functions of Experiment Station veterinarians began to shift increasingly to investigational efforts, in which special appropriations made available by acts of Congress no doubt served as a stimulus.
In a subset of experiments, Cu2+ was applied to shift the voltage-dependence of ShB-IR to more depolarized levels [23], [24] and to bind charge to the protein.
This is not about short-term belt tightening but about experimenting with the values needed to shift to carbon-lite living.
We performed three experiments to extract polarity shifting patterns: I: Shifting positive clues in bad comments II: Shifting negative clues in good comments III: Shifting between positive clues and negative clues.
She found that changing the class of antibiotics used in the experiment led to shifts in the bacterial community, often enriching for different bacterial species.
Time-course experiments of the kind presented here do not easily lend themselves to statistical analysis because even small experiment-to-experiment shifts in the overall shape of the response curves destroy the apparent precision of the individual measurements.
Finally, they abandon the vantage-point experiment, shift to an impersonal view, and finish the story in a conventional way.
In particular, it would be interesting to experiment with shifting additional stages of the interactive application program loop from processors to microarchitectures.
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