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In a single experiment, sequencing is capable of identifying nucleotide substitutions, insertions or deletions, and larger genomic rearrangements such as copy number changes, inversions, and translocations, simultaneously capturing all levels of genomic instability for a given population of tumor cells (Fig. 3) [ 69, 70].
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The certainty of the above polynomial model can be estimated by the coefficient of determination, R 2. The experiment sequence was randomized to avoid systematic errors.
Thirty four of the 37 contigs which mapped to the preliminary experiment sequence belonged to the metacontig assembled from the full genome sequence and were in the correct order.
JMC designed the experiment, sequenced and analysed the libraries and prepared the manuscript.
LGC, SA and JFM conducted fruit experiments, sequencing and macroarray and Northern hybridizations.
KP: quantitative PCR experiments, sequencing of target genes, analysis of the data.
It also integrates genome and transcriptome data, e.g. coding genes, full-length cDNA and miRNA sequences, microarray expression experiments, deep sequencing experiments and single nucleotide polymorphisms (SNPs).
Most of the data (pathways, networks, microarray experiments, sequences, etc).
FY designed and carried out the experiments, sequence and microarray data analyses and drafted the manuscript.
PLB carried out the SSH experiments, sequence analysis and participated in RACE PCR.
ET, MM, GGM, JMGA performed the experiments, sequence analysis and analyzed the data.
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