When designing and analysing their experiments, investigators must also consider the relative lack of stability of some of the cellular constituents detected by '-omics' techniques, such as RNA degradation and repetitive freezing cycles.
In fMRI experiments, investigators typically set out to characterize regional BOLD signal changes to specific stimuli or tasks as 'activations' above a resting baseline or control state - an approach that has been influential in demonstrating how different brain systems respond to different types of external stimulation [2].
When designing their own experiments, investigators can estimate the optimum number of samples to pool pre-capture and sequence per lane based on the effects on capture efficiency described here.
By paying careful attention to study design before starting experiments, investigators can save time and money as well as minimize the probability of false-positive or false-negative results.
In a second phase of the experiment, the investigators used varying amounts of electrical stimulation (called transcranial direct-current stimulation, or TDCS) to either lessen or increase the synesthetes' color experience.
During the experiment the investigators were unaware of the animal's group assignment.
In the barley experiment, the investigators measured a total of seven quantitative traits from multiple environments and a total of 127 mapped markers that cover 1500 cM of the barley genome.
Depending on the goals of an experiment, an investigator may require the measurement of a variety of different pressure parameters, over varying periods of time.
For lack of resources, researchers could conduct only relatively simple experiments; if investigators wanted P32 or other radioactive material, they had to order it 6 months in advance to have some made.
In a remarkable series of experiments, the investigators genetically manipulated mice to allow control of RbAp48 levels.
