"Actually, every experiment had its headaches," says Partington. "With the fire, the big issue was safety we had to shoot the air hockey table remotely, no one in the building.
We have previously demonstrated in a double blind randomized crossover experiment, that intravenous PGE2 induces headache in healthy subjects [13].
These studies raise the question of whether antagonists or desensitizing agonists are a better therapeutic strategy, but in addition they further implicate TRPA1 in headache using preclinical experiments based on human observations.
Secondly, hypoperfusion might induce CSD that might contribute to the headache confirmed by several experiments.
A doctor who gets such headaches, Dr. Robert Smith, founder of the Cincinnati Headache Center at the University of Cincinnati College of Medicine, experimented with crushed ice applied to different parts of his mouth to see what set off the pains.
Nearly a year later, what began as a tiny experiment for Facebook has swollen into a national headache.
These two methods are illustrated with a hypothetical experiment designed to compare the effectiveness of two migraine headache remedies.
Our results can be paralleled by recent experiments showing altered resting state fMRI activity in cluster headache patients [7, 42].
Migraine patients were tested interictally (no headache within 48 hours before and after the experiment).
The leading theory of drug-induced headaches is based in part on an interesting experiment that Dr. Rami Burstein and his colleagues at Harvard Medical School performed in 1999.
One published study, for instance, reported that four out of six people assigned to take OxyElite Pro dropped out of the experiment after experiencing problems like sleeplessness, inability to focus, nausea, headaches and jitters.
