Gene level differential expression then forms the basis for further experiments directed at identifying and quantifying transcript isoforms between samples [44], [51] and de novo identification of unannotated expressed regions [15], [52].
Future experiments directed at identifying proteins that interact with NUP98-HOXA9 and examining its effects on nucleocytoplasmic transport may elucidate the homeodomain-independent mechanisms that contribute to the leukemogenic functions of NUP98 fusion proteins.
Future experiments directed at fine-tuning of the expression level of PML-RARA and the cytokine conditions may produce long-term growth of primary human cells and enable the testing of potential drug candidates; however, for the purposes of the current study, uniform conditions were of primary importance in order to compare the effects of the different oncogenes.
Additional experiments directed at more fully elucidating the function of QIL1 are needed.
There were 8 10 embryos per experiment, with two experiments directed at olfactory epithelium ablation and four at nasal cavity ablation, always unilaterally.
These heuristics collectively allowed us to drastically limit the number of candidate experiments to consider at each purchasing step, typically just to one or two possible experiments directed at investigating each unknown parameter.
Woodall et al. (Nat. Comms 6 8099; DOI: 10.1038/ncomms9099) have just reported (26 August) experiments directed at answering the question of how a cell can generate equal populations of two opposite topologies of EmrE.
Recent experiments directed at a late role for serotonin in LR patterning (Beyer et al., 2012) did not test early roles of maternal serotonin or serotonin receptor proteins because they relied on morpholinos.
Although there was enthusiasm for the quantitative approach to the mitochondrial DNA bottleneck, the reviewers felt that experiments directed at testing the predictions of the modeling are required for the manuscript to significantly advance the field.
However, the main conclusions of the manuscript would be significantly strengthened by experiments directed at imaging native R. sphaeroides arrays and/or confirming the identity of the cholera structures by immuno-EM.
