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Our HLA typing experiment assignment was according to the most common alleles (allele frequency > 0.01), but the Caucasian HLA data (Li et al. [ 13]) did not filter rare alleles.
Based on the observation that apoptosis rates differed between experiments after 24 and 48 hours (see Additional file 1: Figure S3), we included a categorical variable representing the experiment assignment of the sample into the linear regression model used for the differential expression analysis, rendering the resulting tests equivalent to paired tests.
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In the case of C CT-HSQC experiments, assignment transfer was done using the CCPN[ 82] copy function.
Throughout the experiment, the assignment of characters to keyboard positions was as given in Fig. 5, which tended to put the most commonly used items at the beginning of the cursor path (Francis & Johnson, 2011).
JDA collected NMR experiments for assignment, conducted NMR and ITC experiments for Ubl, UblS65E and pUbl R0RBR interactions and pUb-modelling experiments (PRE and heteronuclear nOe), analysed data and wrote the manuscript.
Using a variety of triple resonance NMR experiments, complete assignment of 1H, 15N, and 13C resonances in D2 domain has been accomplished.
These experiments led assignment of two of the four F signals (F2 and F3) to F directly covalent bonded to sp3 carbon and an interleaving domain for the local structure of the minor C2-F3 group among the major domain composed of C2-F2 and sp2 carbon (C1).
In quasi-experiments random assignment is not possible and statistical control of pre-existing differences between groups has to be carefully exercised.
Another possible opportunity for making causal inferences is in natural experiments, where assignment to the treatment is not generated by a purely random mechanism but is exogenous to the system of interest.
This gives you ample time to become familiar with the material and opportunity to experiment with assignments that you will see in Fall.
In all experiments response assignment was counterbalanced across participants.
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