This work offers support for the rapid integration of adult-born neurons into existing circuits, followed by experience-dependent refinement of their functional connectivity.
The proprioceptive differences observed in this study are likely the result of experience-driven refinement in the utilization of somatosensory feedback throughout childhood and into adolescence.
Activity-induced changes in the structure and function of neural circuits are responsible for the experience-dependent refinement of developing connections, as well as the learning and memory functions of the brain.
These results suggest that presynaptic mechanisms play an important role in the experience-driven refinement of geniculocortical axons.
The documentation obtained from this early experience permitted refinement of procedures and development of a user manual.
This was anticipated and with increased use and experience, and refinement of the software interface, it is likely that the time and person burden will diminish.
Further experience and refinement in the technology may result in its use as an accepted method for performing measurements on sub-visible particles in protein formulations.
This is particularly so since, when multiple equilibria exist, out-of- equilibrium dynamics may play an important role in determining which one (if any) is reached, so that without a dynamic theory, current efforts at (static) equilibrium refinement may experience sharply diminishing returns Note 6.
In the second decade of transcatheter aortic valve replacement, clinical experience and refinements in valve design have resulted in clinical drift towards lower patient risk cohorts.
Passengers will experience more legroom, ergonomic refinements, artful eye masks and touchscreen and onboard entertainment enhancements.
One would like to think that wisdom wrought by experience, would inspire refinement of vision, paring of words and clarity of purpose.
