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The loss of malignant cells in the pleura fluid near 4 weeks post-cell infusion happened in one patient and another experienced stable to decreased burden of disease, suggesting anti-MSLN CAR-T cells possessed direct anti-tumor efficacy.
Three patients experienced stable disease (SD) with a mean duration of 37 weeks.
When including all participants in the analyses, including non-survivors, the 3264 people who reported exercising at least as intensely as walking three or more times per week still experienced stable or improved cognition more often (42.3%, 95% CI 40.6 44.0) than did the 4331 who did not exercise this much (27.8%, 95% CI 26.4 29.2).
Six patients (22%) experienced stable disease.
Seven patients (20%) experienced stable disease for >6 months.
A further 15% of patients experienced stable disease.
Eight patients experienced stable disease (median time to progression 4 months, range 4 47+).
None of these patients achieved a meaningful clinical response but half of them experienced stable disease.
Eight patients experienced stable disease for a median duration of 201 (range 59 256+) days.
When asked, the majority of the patients responded that they experienced stable or improved hearing.
A further 523 (30%) patients experienced stable disease, whereas 12% showed signs of primary PD.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com