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To date, she said, she has collected detailed data on about 500 people who report having experienced muscle aches, memory problems, irritability, neuropathy, or other symptoms while taking the drugs.
Mr. LaLanne said he performed his exercises until he experienced "muscle fatigue," lifting weights until it was impossible for him to continue.
The questionnaire also asked about whether or not the runner had experienced muscle cramping during each of the four race segments.
The questionnaire also asked whether or not the runner had experienced muscle cramping during prior ultramarathons and if they had had muscle cramping during this event, with answer options of yes, no, and "almost, but was able to control any full-blown cramping" (subsequently referred to as "near cramping").
Several astronauts have spent more than a year in zero gravity, and they experienced muscle loss, brittle bones and difficulties with vision.
Since Hadley hadn't experienced muscle weakness, she was puzzled by the test results and scrambled to make sense of what appeared to be Dr. Youngman's shift in focus from MSA to neuromuscular disease.
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They may experience muscle and bone pain, fatigue and mood problems — even though tests find no sign of a systemic infection.
Mr. Jones, 37, said he began to experience muscle spasms in his forearms and elbows so severe that they sometimes woke him up at night.
Both elderly people and astronauts experience muscle loss, decreased bone density, sleep disturbances, hormone imbalances, weakened immune defenses and problems with balance and orientation.
Any patients taking Baycol and experiencing muscle pain, or taking Baycol along with gemfibrozil, should immediately stop taking Baycol and consult with their doctors, he added.
No new patients should be put on the high dosage, the F.D.A. said, recommending that existing patients should continue only if they have used the drug for more than a year without experiencing muscle pains.
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