Exact(2)
Virginia Tech experienced a dose of reality.
Genevieve Tenoso, an anthropology major who is a seventh-generation descendant of Sitting Bull, the legendary Hunkpapa leader, experienced a dose of the roiling emotions when she ran into a group of students demonstrating on behalf of the chief under the banner "The Illini Nation".
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The market is experiencing a dose of reality".
Of these, 46 (79%) experienced a dose reduction of more than 10% relative to the dose in cycle 1 for at least one drug.
Nausea and diarrhea were the most common treatment-related adverse effects, and 10.4% of patients discontinued treatment or experienced a dose reduction due to one of these adverse events.
Less than 10% of patients in the pegfilgrastim and filgrastim groups experienced a dose delay, and < 5% of patients received a chemotherapy reduction.
Twelve percent of patients experienced a dose reduction, mainly due to hand foot syndrome or diarrhoea.
The first three patients enrolled in the study received 12 mg m−2 sagopilone, none of whom experienced a dose-limiting toxicity.
If two or more of six patients experienced a dose-limiting toxicity at any dose level, the maximum tolerated dose was exceeded and dose escalation ceased.
Maximum tolerated dose was defined as the highest dose level at which no more than one of six patients experienced a dose-limiting toxicity.
The standard CRM uses a simple parametric model, such as a one-parameter power model or two-parameter logistic regression mode, to characterize the relationship between dose level and the probability of experiencing a dose limiting toxicity (DLT).
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