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Virginia Tech experienced a dose of reality.
Genevieve Tenoso, an anthropology major who is a seventh-generation descendant of Sitting Bull, the legendary Hunkpapa leader, experienced a dose of the roiling emotions when she ran into a group of students demonstrating on behalf of the chief under the banner "The Illini Nation".
Less than 10% of patients in the pegfilgrastim and filgrastim groups experienced a dose delay, and < 5% of patients received a chemotherapy reduction.
Twelve percent of patients experienced a dose reduction, mainly due to hand foot syndrome or diarrhoea.
After Week 24, 18 patients experienced a dose reduction from 10 mg to 5 mg.
Likewise, patients stabilized on 10 mg/day oral olanzapine and subsequently randomized to the highest olanzapine LAI dose (approximately 20 mg/day oral equivalent) experienced a dose increase.
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If none of the three patients experienced a dose-limiting toxicity (DLT), then recruitment began at the next dose level.
If less than one-third of patients at a dose level experienced a dose-limiting toxicity (DLT), dose escalation continued.
If one patient experienced a dose-limiting toxicity, an additional three patients would be accrued to that level.
Escalation of the erlotinib dose for the next cohort only took place if less than 4 of 12 patients experienced a dose-limiting toxicity (DLT).
Escalation proceeded to dose level 3 unless two out of three or four out of six patients experienced a dose-limiting toxicity (DLT) after the first cycle.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com