Throughout the region, there are countless groups of children who experience significant constraint on their capability to learn.
On the other hand, R-genes may also often experience relaxed constraint under conditions where target pathogens are absent and there is no cost of resistance [ 44].
Later stages may experience less constraint because as development progresses gene interactions become more modular, and so it is plausible that perturbations there have only local effects.
As expected under selection for secondary structures, paired sites experience higher constraint than unpaired sites, i.e. significantly lower numbers of conserved optimal codons and consistently lower numbers of synonymous substitutions.
It has been proposed that synonymous sites may experience constraint because they play a role in controlling splicing or RNA stability [ 15].
Thus, overlapping sequences will experience additional selective constraint that our approach does not accurately take into account.
The latter may experience less functional constraint allowing for flexible gain and loss of domains leading to diversity of domain structures.
Given this additional structural and functional importance, it is not surprising that buried residues in both EM and TM regions experience heightened selective constraint compared with exposed residues.
In keeping with the nature and scope of entrenched pluralism, not all actors and groups experience the constraints of pluralism in the same way: from the perspective of some groups, pluralism enables their flourishing; for others, it may be an obstacle.
We compare the performance of RS, BB, and RSBB contracts under a coordinated two-stage supply chain in which members experience budget constraints.
When business cycles contract, the first thing to experience building constraints is infrastructure (Grebler and Burns 1982; Wheaton 2015).
