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Cells regularly experience replication stress at difficult-to-replicate common fragile sites, which are prone to breakage if their replication is unfinished at mitotic onset (Durkin and Glover 2007).
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In cells experiencing replication stress γ-H2AX signals occupy a whole nucleus in a diffuse and uniform manner [20].
The diffuse and uniform manner of γ-H2AX signals in MN-γ-H2AX resembles the distribution pattern of γ-H2AX signals in nuclei of cells experiencing replication stress.
In addition to their occurrence as discrete nuclear foci, γ-H2AX signals can occupy a whole nucleus in a diffuse and uniform manner in cells experiencing replication stress [20] in cells exposed to high concentration of NaCl [21] or in cells exposed to hypoxia [22].
Here, we show that Rrm3 and Pif1, DNA helicases assisting fork progression across pausing sites, are detrimental in rad53 mutants experiencing replication stress.
Checkpoint mutants experiencing replication stress fail to resume fork progression (Branzei and Foiani, 2010; Segurado and Diffley, 2008) and fire additional replicons (Santocanale and Diffley, 1998; Shirahige et al., 1998).
The only moat shielding Snapchat's core experience from replication by motivated competitors is its network of engaged users — and there are legitimate concerns about the depth of that moat.
And therefore we cannot refine a vocabulary for the description of mystical experience by replication of relevant conditions and renewed attention to the phenomenology of the experiences that occur under those conditions.
Tumors progress very quickly following RB1 inactivation and thereby experience DNA replication stress (Tort et al., 2006).
A small proportion of cases experience viral replication in the central nervous system which may lead to permanent neuronal destruction and paralysis [ 9].
Berry et al. report that impact 'is assessed in terms of visitor numbers and characteristics, experiences, and replication activities that emerge from engagement with an eco open home event' (([17], p. 423); see, in a similar vein, [18]).
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CEO of Professional Science Editing for Scientists @ prosciediting.com