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These monkeys had significant sustained CD4 T cell depletion in the periphery as has been reported for cynomolgus macaques infected with SHIV89.6 [27], yet did not experience reactivation by seven months post-SHIV infection (unpublished data).
Although OBI is usually clinically silent, immunocompromised patients may experience reactivation of the liver disease.
RA patients may experience reactivation of latent infection such as tuberculosis, which is the most commonly reported granulomatous infection in patients treated with TNFα antagonists [ 6].
Whether this group is analogous to patients with occult HBV infection 25 who can experience reactivation of viral replication in the face of profound immunosuppression 26 is not known.
The rationale for these inclusions was based on the agent's immune-related mechanism of action, ie, patients who initially experienced clinical benefit might experience reactivation of the immune system in response to further therapy, which may result in recognition and response to residual tumor cells.
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Animals experiencing reactivation early after SIV infection (<17 weeks) had fewer CD4 T cells in the periphery and airways than animals reactivating in later phases of SIV infection.
This has led some authors to propose that these patients are experiencing reactivation of a persistent infectious agent of KD following childhood infection [15].
Four patients experienced reactivation of both CMV and EBV.
Nineteen of the 609 patients (3.20 %) with past infection experienced reactivation after immunosuppressive therapy.
None of these patients experienced reactivation or new onset viral infections or other infectious diseases during the following 12 months.
Each patient experienced reactivation after the end of chemotherapy cycle then, as expected, after the immune response restoration.
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