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Did you experience intolerance there?
However, the patients treated with the second-line TKI also often experience intolerance or resistance, which may require the modulation of drug regiments.
For patients who experience intolerance to first-line imatinib, cross-intolerance to a second-line TKI, or the recurrence of an AE on nilotinib that previously led to imatinib intolerance, is minimal.
The safety profile of mTOR inhibitors generally does not overlap with that of VEGFr-TKIs (Escudier et al, 2007; Motzer et al, 2007, 2010), thus, patients who experience intolerance to VEGFr-TKI therapy may benefit from switching to an mTOR inhibitor.
Similar(56)
Being on methotrexate without experiencing intolerance was associated with higher total, psychosocial, and physical PedsQL scores (all p-values <0.05).
Experiencing intolerance from both sides of the camp made me aware of other people suffering from the same problems.
Our millennial experience with intolerance demands the same acknowledgement as other forms of bigotry.
Juliet Jacques, 33, a journalist and campaigner who documented her transition pre- and post-surgery in a blog for the Guardian from 2010 to 2012, said: "Many young trans people experience discrimination, intolerance, bullying, rejection and violence from several spheres.
After exposure to real (spaceflight) or simulated (head-down bed rest, HDBR) microgravity, astronauts can experience orthostatic intolerance (OI), and become hypotensive and presyncopal when they assume an upright position.
While it is true that the disclosure of adverse effect risk has the potential to result in unintended behaviour, it has been demonstrated that people respond favourably when risk information is framed positively (90% or 90 out of 100 patients WILL NOT experience the intolerance instead of 10% of 10 out of 100 patients WILL).
Nine patients experienced cold intolerance and 8 experienced dysesthesia after 12 months.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com