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Patients carrying ⩾1 mutant ERCC2 allele have a 0.28 times risk to experience grades 3 4 toxicity during treatment with oxaliplatin (CI: 0.10 0.81).
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Patients who had received GCSF were also more likely to experience grade 3 or 4 anaemia.
Radiation therapy was stopped when patients experienced grades 3 4 gastrointestinal toxicities or grade 4 haematological toxicities.
Eight patients experienced grade 4 toxicities.
A total of 25.5 % experienced grade 4 neutropenia.
All patients experienced grade 1 to 3 fevers.
In patients who experienced Grade I−II complications, there was significantly increased improvement in pain and outcome compared to patients who experienced Grade III IV complications.
47% of the patients experienced grade 4 haematological and/or grade 3-4 non-haematological toxicity.
Of the 32 patients treated, eight experienced grade 4 neutropenia and one had grade 4 thrombocytopenia.
During 5FU/IFN treatment, 49 of 50 patients experienced grade 2/3 myelosuppression during course 1.
No patient experienced grade 3+ acute nonhematologic toxicity during concurrent chemoradiotherapy.
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