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Project-creation teams should be assigned a "relevant experience" grade before their crowdfunding campaign goes live, especially in high-tech and manufacturing-centric projects.
Older patients were more likely to experience grade 3+ adverse events (86% versus 79%) with no statistically significant difference in survival.
Patients who had received GCSF were also more likely to experience grade 3 or 4 anaemia.
Only a few cases were reported to experience grade 4 toxicities.
Bevacizumab should be discontinued permanently in patients who experience grade 3 or 4 bleeding during therapy [ 1].
Ixabepilone should be discontinued in patients who experience grade 3 neuropathy lasting ≥7 days or disabling neuropathy.
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As in our study, iTARGET and EURTAC reported generally mild to moderate AEs (rash and diarrhoea), although 13% of patients (11 out of 84) in EURTAC did experience grade-3/4 rash with erlotinib (there were no grade-3/4 rash events with gefitinib reported in our study).
Four patients experienced grade 4 5 late toxicities.
Eight patients experienced grade 4 toxicities.
All patients experienced grade 1 to 3 fevers.
Most patients experienced grade 1 or 2 corneal events (19/35; 54%); 5 (14%) patients had grade 3 events.
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