However, the time-consuming, laborious, expensive experimental determination, such as X-ray crystallographic and NMR spectroscopic measurements, alone cannot catch up the pace with the rapidly increasing number of biologically significant RNAs such as noncoding regulatory RNAs.
However this is computationally expensive and the determination of damping ratios is also inconvenient.
The SA-GC-AFS system is the good, low cost alternative to the expensive commercial automated MeHg determination systems.
Determination of blood glucose is limited by the influence of multiple factors (prior intake, drugs, stress, etc).. HbA1c measurement, although more expensive than blood glucose determination, provides information on the glycaemic environment during the previous 2 to 3 months.
In cases where concentration of coarse particles exceed around 15% by volume the conveyor channel obtains an alternative to expensive commercial viscometers for determination of rheological parameters of viscous debris flows.
Other phenomena occur earlier in the course of diabetic nephropathy, such as glomerular hyperfiltration [ 3, 4], renal hypertrophy [ 5], and renal histologic lesions [ 6], but their assessment in day-to-day clinical practice is inconvenient: renal biopsies are invasive, GFR determinations are expensive and GFR estimations are not useful for diagnosis of hyperfiltration [ 7, 8].
Even if it is measured using a standard 20 L sphere test, its determination is quite expensive and time consuming.
A computer-aided method has been developed for subsite mapping of α-amylases, which substitutes the difficult, expensive, and time-consuming experimental determination of action patterns to crystal structures based energy calculations.
The genotyping approach remains the gold standard of allele frequency determination; however, less expensive, much easier to perform DNA analytical methods for investigating pooled DNA samples have been recently introduced or are currently under investigation.
Using UV absorption for CHX determination needs both expensive quartz cuvettes and a sample volume of at least 3 ml.
