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The major limitation of using these methods is the expense of identifying large numbers of subjects with and without the full spectrum of the primary trait.
Amongst all methods used, linear SVM, radial SVM and LR have the highest sensitivity in identifying recipients with DGF (83.8, 88.8 and 85.5 %, respectively), at the expense of identifying recipients without DGF (72.0, 57.9 and 65.0 %, respectively).
We adopted this strategy rather than the classic Bonferroni correction method because the latter is not appropriate for testing associations within complex correlation structures and is designed to overlook true associations at the expense of identifying spurious ones.
However, the urine LAM test had comparable test sensitivity to sputum AFB, and, when combined with sputum AFB testing, added 20% to the true positive rate, though at the expense of identifying an additional 9.6% as false positives.
In addition, creating more extreme cut points, such as the top decile of risk, would have resulted in higher relative risk differences at the expense of identifying an increasingly smaller number of participants, which would have diminished the clinical relevance of our results.
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However, this came at the expense of not identifying one, but multiple problems that would need to be tackled.
Preliminary studies have demonstrated that CAD programs are capable of identifying some polyps missed by CTC readers, but at the expense of false-positive findings [ 56].
Users can dig through the 700,000 documents of MPs' expenses to identify individual claims, or documents they think merit further investigation.
Hunter (R-Alpine) has already reimbursed his campaign account for $12,000 of expenses he identified as personal or mistaken on campaign finance reports, including video games, oral surgery, private school tuition, a garage door and unspecified items at a Coronado surf shop.
Indeed, Spine also allows inclusion of incomplete or draft genomes when generating the core genome sequence although at the possible expense of some specificity in identifying the accessory genome.
The criteria maximize sensitivity at the expense of specificity: they typically identify 98% of pleural exudates, but they misclassify approximately 25% of transudates as exudates [ 7].
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