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Although total household expenditures and total health expenditures did not differ significantly between excluded patients and included patients, it is still possible that excluded patients were poorer than patients who were included in the study.
However, after adjustment for multiple comparisons, ANOVA tests found that mean expenditures did not differ significantly by treatment group at week 70, controlling for health expenditure by individuals in the 6 months before the start of the trial.
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Since mean energy intake and energy expenditure did not differ between the two groups, the differences in the aforementioned parameters are most likely due to differences in macronutrient relations.
Doubly-labelled water measurements over one day in 15-day old house martin nestlings showed that daily energy expenditure did not differ between infested hosts and controls.
However, the total energy expenditure did not differ between the TB and the AL, presumably because of the drop of activity in TB.
Multivariable regression determined that the expenditures on injections did not differ in a statistically significant manner between aflibercept patients and ranibizumab patients (Table 4: Cost Ratio [CR] treating ranibizumab as reference category = 0.96, 95% CI 0.89 1.04, P = 0.338).
Again, expenditures on injections did not differ in a statistically significant manner between aflibercept patients and ranibizumab patients (Table 4: CR treating ranibizumab as reference category = 0.92, 95% CI 0.74 1.13, P = 0.4291).
For the year of enrolment, we assumed that, on account of propensity score matching, the expected health expenditures prior to enrolment did not differ systematically between the participant and the control subject.
Energy expenditure and locomotor activity did not differ from controls, nor did food intake (Fig. 6d f and ESM Fig. 8a, b).
Comparing between patients who were treated with aflibercept or ranibizumab, the two newest and most commonly used FDA-approved therapies for wet AMD, we found that the number of intravitreal anti-VEGF injections and healthcare expenditures on intravitreal anti-VEGF injections did not differ in a statistically significant manner.
Health expenditures for other members of the household did not differ significantly by CD4 count (p = 0.77).
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