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It can also be used to check the position of the baby and the placenta, the baby's expected weight and the amount of amniotic fluid present.
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For these useful calculations to be made, the expected weight loss and weight gain must be known.
With the expected weight, centres and corresponding standard deviations obtained from the training process, we calculate the genotype likelihood, decide the genotype and estimate the genotype quality for each individual (see Additional file 2: Supplementary Methods for details).
Even if other factors were involved in worsening the disease condition of Ccl3 −/−; Npc1 −/− mice, none of the expected weight gains and sustainability demonstrated with the Sandhoff model was observed.
The correlation between percent expected weight loss achieved and delta energy intake approached significance (r=0.351 P=0.086).
As expected, weight, organ function and age top the list of factors described as critical by questionnaire respondents (Appendix, Question 8, see Additional file 1).
Nutritional status at admission was judged by a combination of subjective clinical assessment, body weight record (labeled underweight when <10th percentile of their expected weight as per sex and height) and serum albumin levels <3.0 g/dl was considered low.
One third (32.1%, 9/28) gained sufficient weight to reach 95% of the expected weight for their age and sex.
A further four patients reached 95% of the expected weight for their age and sex resulting in 44.8% (n = 13/29) of the treatment completers meeting this criterion.
In each group (intervention and control) 130 participants will be needed, based on a power of 80% and an alpha of 5%, and an expected weight loss of 1.5 kg (sd 4.3 kg) as result of the intervention.
Dutch guidelines are in place to recommend whether or not to start active neonatal management by a neonatologist in cases with spontaneous preterm labour and an expected weight appropriate for gestational age.
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