The practical identifiability analysis for the available experimental schemes indicated high correlation between some pairs of parameters in the subset and large expected uncertainties for the parameters.
Figure 10 shows the evolution of the expected uncertainties for all parameters throughout the identification procedure and Figure 11 presents the comparison of the ellipses for the most and the lest correlated pairs of parameters (detailed plots of the expected uncertainties by pairs of parameters are shown in the Additional file 1: Supplemental Figures S4 and S5).
In terms of quantitative accuracy of estimates and expected uncertainties for translation to clinical measures of absorbed dose, Table 5 shows the average errors and ranges of measures for those reconstructions that were found to be best, based on the data investigated in this work.
This work presents rate coefficients and product distributions for the temperature range 300 3000 K, and pressure range of 10−3 103 bar; a brute-force error analysis examines the expected uncertainty interval for these predictions.
The results indicate that even the minimum expected uncertainty in, for example, measurements of microbubble radius using conventional optical microscopy, leads to variations in the estimated coating parameters of ∼20%.
In addition the expected uncertainty has substantially improved as compared to the expected uncertainties found for the experimental scheme ES1.
In this work, stochastic simulations for expected uncertainties in feedstock composition, kinetic parameter values, and operational parameter values for these two steps were performed.
We expect uncertainty estimates for information used in chemical evaluations to evolve with the availability of more measured data and improved measurement techniques, better QSA(P R models, and experience.
Expect more commercial stations to go to the wall, expect BBC Radio to be less sure of itself than it has been for years, expect uncertainty over DAB to continue for some time to come - expect a bloody battle.
Finally, decision-makers should expect uncertainty and act accordingly.
