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This observation may be explained by the higher proportion of urinary midazolam excretion in the presence of developmentally immature CYP3A4/5 activity as an active CYP3A4/5 enzyme which would be expected to markedly reduce midazolam clearance due to drug biotransformation.
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Excessive running load is expected to markedly exceed the animals' normal physiological running activities.
After the president's announcement, the frequency of strikes is likely to markedly reduce.
Late last month the Supreme People's Court announced reforms intended to markedly reduce executions.
SiRNA-mediated depletion of PXR was found to markedly reduce BC formation due to FSK treatment, without however fully abolishing it (Fig. 6a,b).
This combination of inducible conditional systems leads to markedly reduced viability (as would be expected for Ddc2-depleted cells), and a rapid decrease in Ddc2 levels when cells are treated with tetracycline and auxin.
Interestingly, this was due to markedly reduced basal Akt activity compared to monolayer cultures (0.04 ± 0.02 vs. 0.21 ± 0.01 pAkt473/totalAkt).
Surprisingly, inactivation of the viral protease led to markedly reduced shedding of gp120.
Proactive culling markedly reduced local densities of badgers [20], which would be expected to reduce the overall risk of cattle coming into contact with badgers.
Although it would not be expected to reduce mortality and long-term morbidity rates markedly compared with a carefully monitored glucose infusion, octreotide does have some advantages.
As expected, this combination markedly reduced C33A cell colony formation leading to a synergistic interaction (R=0.58; Figures 4A and B), with concomitant reduction of MAPK and AKT phosphorylation.
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