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The effects of the warming are expected to be profound: if global warming has occurred as rapidly as some climatologists have suggested, the mean temperature of Earth's lower atmosphere will increase by 1.8 to 4 °C (3.2 to 7.2 °F) by 2100 over baseline temperatures established in 2000.
Anti-Aspergillus prophylaxis should probably be used in critically ill neutropenic patients with acute myeloid leukemia or myelodysplastic syndrome with both induction and consolidation therapy used when neutropenia is expected to be profound (neutrophil count less than 500/mm3) and with an expected duration of at least 15 days (Grade 2+, weak agreement).
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Thus, orally available and selective small molecule inhibitors of individual GRKs are expected to be of profound clinical importance not only for cardiovascular function but also in essential hypertension, Parkinson's disease, and multiple myeloma.
The detrimental effect of ROS is expected to be uniquely most profound in the lung due to its constant exposure to the high oxygen tension of the ambient atmosphere.
The nth-1 xpa-1 double mutanth-1 xpa-1re profoundoublerepair defect and is expected to be unable to repair a mutantider spectrum of DNA lesions.
Expect to be nervous.
What exactly the shape of a future world order will look like is unclear, but leading players expect the changes to be profound.
The consequences are proving to be profound.
The deep experiences have to be profound".
Perhaps it's not surprising: Christmas is a relentlessly commercial period in which we're expected to experience profound peace and joy while being forced to cohabit with people who often inspire neither emotion.
This shift to M2 clearly is expected to have profound consequences, since it is not the normal state in health, and extended long-term activation of M2 macrophages is associated with the establishment of chronic lung disease [ 53].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com