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Due to their conservation pattern, these family-specific amino acid residues are expected to be functionally relevant and are likely correlated to specific molecular and physiological functions of the respective protein families.
The types of protrusions formed by Rac, Rho or the cooperation of Rac and Rho are expected to be functionally redundant, but could in fact be fundamentally different in structure or their function altered by the 3D environment.
The structurally intact AChRs are expected to be functionally "silent" under physiological conditions (Fig. 1A, B; see Material and Methods).
In general the overlap was not larger among similar traits (chill coma recovery, starvation and longevity/life span) than among traits not expected to be functionally correlated.
We explored several algorithms and various training sets with different positive/negative ratios in order to reach a good compromise between the actual underlying class unbalance (most protein pairs are not expected to be functionally related).
Fortunately, it is possible to assess the accuracy of Hox-protein classification schemes by examining whether the Hox-proteins, expected to be functionally similar based on the classification, actually lead to similar mis-expression phenotypes in vivo.
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Since the SVM model can easily avoid falsely connecting functionally dissimilar proteins, the resultant interactions are expected to be more functionally coherent and can further improve protein annotation.
First, the human iPSCs-derived cardiomyocytes that stably expressing the apoA-I is expected to be a functionally improved cell sources for transplantation, more importantly, after transplantation, these cells may act as an internal sources of the apoA-I that may lead to the increased local HDL-C levels in the infarct sites that could be beneficial to the recovery of myocardial infraction.
This was expected as coding sequences are expected to be more functionally constrained than noncoding sequences.
Furthermore, not all real modules are expected to be completely functionally homogeneous (Spirin et al., 2003).
Since they diverge from the same ancestor, duplicate gene pairs are expected to be more functionally related than non-duplicate pairs in the topology of biochemical networks.
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