Sentence examples for expected to be deleterious from inspiring English sources

In this model, a large number of the variations observed would be expected to be deleterious, at least to some extent.

Some translocations, for example, would be expected to be deleterious to the cell, since two different gene alleles (one allele of each gene) have been inactivated by the breaks, so that cells carrying those translocations will eventually disappear from the tissue.

Although most TE-caused mutations are expected to be deleterious, some are neutral or even adaptive.

Thus, kinetochore formation on essential genes would be expected to be deleterious.

This mutated protein would be expected to be deleterious, having reduced affinity for GC-box binding sites in promoter regions.

The breast cancer associated mutations identified in PALB2 are expected to be deleterious, and all result in protein truncations.

High frequency polymorphisms are not expected to be strongly deleterious (see [ 34]), but rather, will consist of neutral and slightly deleterious mutations – mutations that can potentially become fixed via genetic drift.

A sizable proportion of all polymorphisms in the human genome (SNPs, indels and CNVs) are expected to be weakly deleterious and not destined to become fixed.

However, recent mutations are expected to be more deleterious also in the absence of population growth.

The frameshift mutation, 10941del TAACAACCCCC, causing frame-shift and premature termination at amino acid 110 of ND4, is expected to be a deleterious mutation.

Different SNP types are expected to vary in the intensity of negative selection against them; for example, missense mutations are expected to be more deleterious than are silent mutations [ 16, 17].