In general, as expected the sensitivity of the assay was improved by sensitization of the erythrocytes with specific antibodies, which enhances the activation of the classical pathway (IgG and IgM) and the alternative pathway (IgG).
In this way, multiple radio- and chemo- sensitization expected with such a regimen may result to an increased anti-tumour effect but, also to an increased toxicity.
A robust accumulation of eosinophils in BALF, as expected, accompanied OVA sensitization and challenge in OVA/ALL mice (up to 1.1 ± 0.2 × 10 cells/mL vs none in PBS control).
Taken together, these studies lend substantial weight of evidence that MMA should not be expected to cause respiratory sensitization.
Although limited, these study findings provide no evidence that MMA should be expected to cause respiratory sensitization.
Cys in the SD and Cys in the IBC of IP3R1 therefore have the properties expected to explain the sensitization of IP3R1 and IP3R2, but not IP3R3, by thimerosal.
The PI(3 K-C2α peptide prevented the sensitization after inflammation in wt mice, and as expected it did not affect sensitization to nerve injury (Fig 3I,J).
This would suggest that the higher prevalence of CBD in our study population was not solely related to the long latency since last exposure because we would have expected a lower rate of sensitization alone without CBD if increased prevalence of CBD was solely caused by the long latency.
The patients with RA, compared with healthy control individuals, had lower mechanical pain thresholds, lower heat pain thresholds, and lower cold pain tolerance, all of which are expected in a situation with peripheral sensitization to noxious stimuli [ 2].
In sum, we either found no exposure response or the significant exposure responses we did find were in the opposite direction than expected, with individuals with CBD or sensitization having less estimated exposure than those with no beryllium disease.
