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Although all expected samples with 11q LOH were detected by both methods, 4 samples previously determined to have whole chromosome 11 LOH by microsatellite mapping actually had areas of chromosome 11 without LOH on SNP array analysis.
However, as expected, samples with ploidy disagreement were also discordant in their copy number profiles.
As expected, samples with a low PMR value displayed few methylated CpG sites from the bisulfite sequencing analysis, whereas several of the clones from samples with higher PMR values had methylated CpG sites.
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As expected, sample with the highest surface area, C3060, possesses the highest gravimetric capacitance at all examined discharge current densities (0.2 2 A/g).
As expected, samples spiked with recombinant human IGF-I (concentration range 19 1245 ng/ml) showed an excellent mean recovery rate of 91.6% (range 81.1 101.1%).
As expected, samples from subjects with COPD had a higher mean and a greater range of Lm values between samples compared to those from donor lungs, indicating that there are regions of severe emphysema in COPD subjects (Table 1).
Consequently, the total expected sample volume with the above assumptions was approximately 3500 cases in 2001, 3500 cases in 2006 and 7000 cases in 2011.
With an expected sample size of 3,000 (including the sample in Hamburg) a more detailed analysis will be possible.
Of the 49 large rearrangement positive samples processed, 48 produced results which were all concordant with the expected sample large rearrangements.
In the UK a 3-arm RCT of robot therapy with an expected sample size of N = 720 is currently being undertaken (http://www.nets.nihr.ac.uk/projects/hta/112605).nihr.ac.uk/projects/hta/112605
With an expected sample size of 21.4 for a tolerability rate of p0 = 0.70 (i.e., under the null hypothesis), this design shows similar characteristics as Simon's (1989) optimal design whose expected sample size is 21.2.
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