As expected, insulin resistant cells displayed reduced GLUT4 translocation in response to insulin (panel A).
As expected, paclitaxel-resistant cells showed cross-resistance to 17-DMAG, and the inhibition of P-gp restored sensitivity to 17-DMAG in paclitaxel-resistant cells (Fig. 5d- f).
The formula for the probability of resistance for any fitness value and the expected number of resistant cells is derived in Iwasa et al, 2006.
Instead of considering the proportion of patients that develop resistance, it is also useful to investigate the expected number of resistant cells present within a patient for a given mutation rate, u.
As expected, only the resistant cells survived TMZ treatment in the untransfected cells, shown as ∼35%.
An "activated" upstream regulator indicates a molecule expected to be more active in the resistant cell lines than in the parental ones.
Un-expectantly, cyclosporin A did not noticeably inhibit MDR1/PgP expression in any of the cell types, but possibly the expression of Gb3 in the resistant sub-lines, whereas PPMP, as expected markedly, reduced not only Gb3 expression in the resistant cell sub-lines, but also of MDR1/PgP expression, especially of the cells of the resistant cell lines with also high expression of Gb3.
As expected, most of the 35 genes from the signature of response did not change upon treatment in the resistant cell lines.
As expected, the puromycin-resistant cells recovered from the diseased mice express Bcr-Abl.
As expected, the anti-oestrogen-resistant cell lines, MCF-7LCC1 and MCF-7LY2, appeared less responsive to OH-TAM regarding cell proliferation compared with MCF-7 or MCF-7 7AZ (Table 1).
