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As expected, prognostic value was not seen for all genes when tested across a larger number of samples.
The effect of the primary adjustment variables (age, sex, Hardman index and maximum aortic diameter) is shown in Table 3: the expected prognostic value of the Hardman index is observed.
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Since it is expected prognostic factors have different effects between surgery patients and non-surgery patients, the impact value of all variables and the corresponding interactions with surgery on survival were evaluated in Cox proportional hazards regression model.
Therefore we had expected a prognostic value of IMP3 in prostate cancer, as has already been shown in other malignancies [ 6- 23].
Even though we would expect the prognostic value of VBR to be evaluated in association with the clinical appearance of the patient, we did not detect any closer association in the outcome analysis.
The gene expression set was also tested in renal cell carcinoma, a tumor with a weak stromal response, where it was not expected to have prognostic value.
This finding was rather expected, since the prognostic value of the markers examined remains contradictory, as supported in recent meta-analyses for ERCC1, which also stress the need for standardization methods to assess gene expression by qPCR in tumors [ 27, 30].
We first evaluated whether the tumor stage (pT) of the disease, as we could expect, had a prognostic value in our series of GC patients.
Stage is expected to have a prognostic value in colon cancer.
Indeed, any biomarker is expected to have some prognostic value and sepsis biomarkers are no exception; however, this is not an absolute rule because some sepsis biomarkers failed to have prognostic value [ 37- 39].
The variables selected to be excluded were not expected to have any prognostic value or alternatively were known to be highly inter-correlated with other scales, thereby not contributing to the model.
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CEO of Professional Science Editing for Scientists @ prosciediting.com