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As Brown and Benyon-Jones showed, the promise of areas such as human-animal hybrid embryos for research and medicine has been left unfulfilled, as indeed is the case for much that was expected of human embryonic stem cell research.
Finally, we need to bring the rigor and quality of study design that is expected of human clinical trials [see CONSORT 2010 statement (Schulz et al., 2010)] to animal trials that test candidate therapeutics.
In summary, while showing the electrocardiographic QT and QTc prolongations expected of human LQT3, murine ΔKPQ1505 1507 hearts demonstrated both compromised SAN function and slowed atrial conduction, in common with findings associated with the loss-of-function Scn5a+/− mutation (21).
Given the remarkably low success rate in translating preclinical research into clinical success, a number of disease-focused groups, including the NINDS, are recognizing the urgent need to raise the standards of preclinical studies to encompass the rigor and transparency that is already expected of human clinical trials [see CONSORT 2010 statement (Schulz et al., 2010)].
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When adding a high-fat diet, most rodents exhibit a diet-induced obesity response similar to what is expected of humans who over-consume a calorie-rich, high-fat diet.
It is too much to expect of human nature that people should freely acquiesce in and embrace such terms of cooperation.
In addition, the Government will consider whether a higher standard of "driving" should be demanded of automated vehicles than would be expected of a human driver.
As expected of cultured human fibroblasts, CMp11 contained high concentrations of lactate [33], [34] as well as lower concentrations of the commercial L-glutamine source, GlutaMAXTM that when hydrolysed by aminopeptidases in the culture media, produces detectably higher levels of alanine.
Indeed, using forward primer NGLY1-10long and the reverse primer NGLY1-8 (Table S1), the major PCR product (339 bp) expected of the published human NGLY1 mRNA sequence [20] and a minor PCR product of 161 bp were detected.
Adenosine diphosphate (ADP) (final concentration 6.5 μM) induced platelet aggregation to an extent expected of that for human blood (area under the curve (AUC) 738 ± 125.87 AU*min).
Federal law explicitly requires abstinence programs to teach that "sexual activity outside the context of marriage is likely to have harmful psychological and physical effects," and that "a mutually faithful monogamous relationship in the context of marriage is the expected standard of human sexual activity".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com