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(iii) Coverage distribution: this defines the expected number of trials in the Poisson distribution.
To estimate the expected number of trials with statistically significant results, estimates of the unknown true effect sizes for each meta-analysis in the network are required.
We test whether O, the observed number of trials with statistically significant results at a specified α level, differs from E, the expected number of trials with statistically significant results.
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The cohort of studies will consist of all studies that registered their stop date between January 1st 2005 and January 1st, 2010 (expected number of available trials N≈1000).
Patient competition must be estimated from knowledge of ongoing or planned trials, potentially run or funded by other groups and estimates of those factors could be used to adjust the parameters used in the predictive model - for example by reducing the expected number of patients recruited while a competitive trial is underway.
Response-adaptive designs have been shown to be useful in reducing the expected number of patients receiving inferior treatments in clinical trials.
Expected number of failures.
expected number of crashes.
Data represent expected number of cases (prevalence).
32, 33 In a simulated cohort of 10,000 patients using a decision-analytic model with parameter estimates derived from published clinical trials, expected numbers of deaths attributable to VTE or drug complications were 37 with enoxaparin 40 mg once daily, 53 with unfractionated heparin 5000 IU twice daily, and 81 with no prophylaxis.
The total number of expected coincidences within the window is derived from the sum of the expected numbers per trial: n exp = ∑ j = 1 M n exp j.
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