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Many of most prominent genes are, as expected, known SOS genes (umuD, recN, umuC, sulA, tisB, dinI).
In this study, expected known class-effect toxicities related to mTOR inhibitor therapy were observed, including anemia, hypertriglyceridemia, hyperglycemia, hypercholesterolemia, pulmonary events, and stomatitis.
Our calculations applied to a cancer dataset find expected known genomic alterations and many others identified as key altered genomic regions.
A similar inability to identify all expected known genes after SSH was recently reported by others and ascribed to incomplete representation of the total cDNA repertoire [ 31].
Expected known class-effect toxicities related to mTOR inhibitor therapy were observed, including anemia (64%), hypertriglyceridemia (55%), mouth ulceration (53%), hyperglycemia (52%), hypercholesterolemia (50%), and pulmonary events (31%).
As expected, known p53 targets like MDM2 and CDKN1A were significantly higher expressed in the p53 functional group than in the non functional group (p=0.0025 and p=0.0013 respectively).
Similar(42)
And they don't seem likely to be all that relieved just because fewer people than expected know about it.
Since PdhR is known to repress the transcription of most of its targets, we expect known targets of PdhR to have a high regulatory score in our experiments.
"Know what to expect, know what not to expect.
"Those pockets of weakness were in areas already expected and known," he said.
Other relevant side effects are not expected if known contraindications (see exclusion criteria) are respected.
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CEO of Professional Science Editing for Scientists @ prosciediting.com