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This is expected in populations of highly variable RNA viruses and implies that non-synonymous substitutions can be highly deleterious [68], [69].
Overall our calculations suggest that a stable equilibrium for these fecundity alleles might only be expected in populations of large size (Ne>400) [15] under favourable or predominantly favourable environmental conditions.
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Note that for these two poison-impacted scenarios the mean trajectories were quite similar, except for the largest variability expected in population trajectories when the impact of poisoning was temporally correlated (scenario 2 Fig. 5).
Since the chimeric sequences vary considerably in different genotypes, and a large number of distinct genes of this lineage are expected in natural populations of T. kirilowii.
This estimate of Ne can be quickly compared with the heterozygosity expected in contemporary populations of B. taurus as the heterozygosity expected is (3) where μ = the mutation rate per generation.
Strong selection/slow fluctuation limit: When the duration of a sweep becomes much shorter than the timescale over which population size changes, the probability of observing a soft sweep in the cyclical population model converges to that which is expected in a population of constant size Ne t0), the effective population size at the starting time of the sweep.
Weak selection/fast fluctuation limit: When the duration of a sweep becomes much longer than the period of population-size fluctuations, the probability of observing a soft sweep converges to that expected in a population of constant size, given by the harmonic mean of Ne(t) estimated over a population cycle (dash dotted line in Figure 4B).
Strong selection/slow fluctuation limit: When the duration of a sweep becomes much shorter than the timescale over which population size changes, the probability of observing a soft sweep in the cyclical population model converges to that which is expected in a population of constant size N e(t 0), the effective population size at the starting time of the sweep.
Once determined to be at increased risk, all eligible women were offered the opportunity to take tamoxifen, thus minimising potential selection bias and as such our results may therefore reflect an approximation of uptake expected in this population of premenopausal women attending FHCs.
The levels of the inflammatory markers we observed in our study population of individuals with heart failure were elevated, as expected in a population of heart failure patients.
A significantly higher prevalence of abnormal lumbar displacement kinematics in a prospective cohort of patients with LBP, than would be expected in a population of asymptomatic individuals, would be evidence in support of LSMDs being valid diagnostic entities [ 13].
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