The fact that microbial genomic diversity is caused by both vertical mutations and horizontal transfer makes it also plausible to expect heterogenous detection probabilities.
'Type 4' drugs, which produced inhibition with properties between 'Type 1' and 'Type 2' were classified together with either of these groups, and unclassified drugs, as expected, were heterogenous, and were scattered among the three major clusters.
Finally, site-stripping approaches (Brinkmann and Philippe 1999; Pisani 2004; Sperling et al. 2009) can be used to eliminate rapidly evolving sites and limit LBA artifacts because the most rapidly evolving sites are expected to be the most heterogenous in composition.
Given that TF expression levels and TF-TF interactions are cell type-specific [ 21, 26], the expression prediction models are expected to be less accurate for heterogenous samples.
The reference group is mothers born in England and Wales and while this has a sex ratio of 1.054 which is within the expected range [ 1], this will itself be a heterogenous group of individuals.
Among the samples analyzed here, therefore, we expected that the human datasets would represent measures of genetically heterogenous individuals, whereas the mouse datasets would often come from inbred lines.
The sites from the internal quartiles are expected to be homogenous among them, whereas sites from external quartiles are intrinsically heterogenous.
However, unlike cytosolic ChaC1, which migrates at a position expected of the reduced monomer on non-reducing SDS-PAGE, ER-localized ChaC1 migrated as a heterogenous collection of species, consistent with inappropriate disulfide bond formation (compare the reducing and non-reducing SDS-PAGE in Figure 2A and Figure 2 figure supplement 1).
"Expects," not "expected".
As dry eye is a heterogenous condition, one expects in clinical studies that groups of patients with varying disease severity and tear parameters are included.
