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These genes passed the Student's t-test at the threshold of 0.05 and the associative t-test at the threshold of 0.0005, a stringency that results in the selection of less than one expected false positive and less than one expected false negative determination.
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K0 (weight = 0) is recommended if expected false negatives (PQ') have zero utility; K1 (weight = 1) if expected false positives (P'Q) have zero utility (see Additional file 1 for details).
As expected, false-negative results to any of the immune assays considered were associated with factors known to cause anergy such as disseminated disease.
Having demonstrated that the local fdr statistic reliably produced a low false-positive rate for the k252a experiments, we then evaluated whether statistical power diagnostics could be used to reason about the expected false-negative rate.
However, F-test with outlier removal has a higher than expected false-negative rate (i.e. it fails to identify at least 99% of the true DV genes).
As these effects are close to the G/NG criteria, we would expect false-negative results to be more common than observed for the marketed test compounds.
29– 31 Both the ACOSOG Z1071 clinical study 30 and the SENTINA study 31 obtained higher-than-expected false negative rates (12.6 and 14.2%%, respectively).
Although it is possible some of these benign lesions were given an incorrect diagnosis, we expect the false negative rate to be very low, probably negligible, given that the diagnosis was made by an expert dermatologist with over 15 years experience in dermoscopy.
Because radiographs were part of our screening, we would expect the false negative rate for CBD to be lower than the potential false negative rate for sensitization.
In this setting, it appears quite optimistic to expect a false negative rate of <5%, especially in centres where breast cancer surgery is only occasionally performed.
Specifically, it is reasonable to expect that the false negative rates for these networks could be quite high, although the false positive rates are low.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com