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Furthermore, for consequence assessment and countermeasures application, it is more realistic to rely on the maximum expected dosage rather than on the actual dosage.
We only included variants with an expected dosage r 2 ≥ 0.8 for the eQTL mapping.
Following the question 1., a comment on the expected dosage would help to clarify most of these issues.
Another limitation of our study was the relatively low analgesic demand of the patients during the observation period, which was less than 50% of the expected dosage.
He explained the deviation from the expected dosage effect by "genomic imprinting", i.e. the overexpression of R and/or repression of L genes in offspring through the maternally inherited R genome.
For ITT analysis, patients who received more than one dose of peg-IFN were enrolled, and drug discontinuation was defined as discontinuation of the treatment without completing 80% of the expected dosage.
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In conformity with an expected dosage-dependent change in expression, the vast majority (579/596) of the differentially expressed genes exhibited less than a two-fold change in transcript levels in wild-type relative to DpDf plants.
Regressing on expected dosages incorrectly models uncertainty in the predictors.
Including the expected dosages of common haplotypes and the rare haplotypes (combined into a single variable) as covariates in a logistic regression model with the most common haplotype as reference, gave a global p (likelihood ratio test) of 0.0493 in relation to breast cancer risk (Table 3).
First, one may not expect dosage compensation in testis and the authors did notice that the key component of dosage compensation, msl-2, does not appear to function in testis.
Intriguingly, the observed dose-dependency of ionizing radiation-induced p21-activation on p53 gene expression levels fits a sigmoidal dose response model with an apparent IC50 around 50%p53-expressionp53-expressiond gene dosage of a p53+/- heterozygote.
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