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These approaches do not allow for drawing inferences related to expected cost effectiveness during early clinical development.
Indeed, some economists have argued that reliance on traditional rules of statistical inference surrounding a single parameter, such as clinical effectiveness, is arbitrary and may result in inferior healthcare outcomes compared with decisions based on expected cost effectiveness.
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We propose a hydro-economic model that combines a hydrogeological model to simulate groundwater quality evolution with agronomic and economic components to assess the expected costs, effectiveness, and benefits of AES implementation.
Let me hasten to add that I do not know whether that actually is the expected cost-effectiveness ratio for statins (where the "cost-effectiveness ratio" is defined as the cost per unit of health care outcome achieved — here one life-year).
To evaluate the expected cost-effectiveness and net benefit of the recent implementation of newborn screening (NBS) for severe combined immunodeficiency (SCID) in Washington State.
How this benefit is calculated and considered in spatial prioritisation analyses could influence the expected cost-effectiveness of management, although this has not previously been explored.
This corresponds to an expected cost-effectiveness ratio of $US 35 '000per QALY gained (Table 4).
In this situation (i.e. 20 runs per scenario) the incremental cost-effectiveness never exceeded the €10,000 per QALY for both scenarios which makes it plausible that the expected cost-effectiveness is very likely below this value.
This illustrates the uncertainty surrounding the estimates of expected cost-effectiveness (in €) between IRR and UC.
The results from the sensitivity analysis are presented in the appendix and generally conform to the expected cost-effectiveness results reported for the primary analysis.
In terms of the expected cost-effectiveness, the probabilistic results are summarised in table 3 and presented graphically in figure 1 in the Appendix.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com