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In biological candidate studies, insights from phenotypic information have been used to investigate whether candidates of interest, usually single genes with a prior expectation of evolutionary significance, show genetic evidence of positive selection.
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If the variation is significant, it exceeds the expectation of neutral evolutionary models [ 20] and thus is consistent with evolution by natural selection.
We can use relative rates of evolution via artificial selection as a priori expectations of relative evolutionary rates via natural selection (Bone and Farres 2001).
We finally measure the rate of evolution of the morphological traits to see if they fit the theoretical expectation of faster morphological evolutionary rate [ 4, 31].
We used a posterior predictive approach to determine whether the observed MDI differed from the various evolutionary expectations of the different evolutionary models [ 39].
Changes in the AP biology course and the MCATs will drive student expectations for thorough coverage of evolutionary biology, and the intersection between evolution and medicine provides engaging and informative examples of key evolutionary concepts.
However, the expectation that a similar degree of evolutionary constraint might also be observed at exon 3 of PAX9 was not confirmed by us [4].
Deviation from this neutral expectation can reveal fundamental aspects of evolutionary and biological processes [ 32, 45].
Alternatively, if signaling by the external environment dominates, ribosomal biogenesis gene expression will be higher in glucose, in accordance with the evolutionary expectation of higher growth rate of wild-type cells in glucose.
The concept of layers of homology treats change as a discontinuous process, inconsistent with the expectation of change given the evolutionary model.
Consistent with this expectation, molecular evolutionary studies of genes in primates, Drosophila, and plants have shown that immune-related genes tend to evolve adaptively and are among the most rapidly evolving genes in the genome (Clark et al. 2003; Schlenke and Begun 2003; Nielsen et al. 2005; Tiffin and Moeller 2006; Sackton et al. 2007).
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