Thus evidence for benefit in terms of efficacy can be said to exist when ADT is combined with radical local therapy, but only in men with sufficient life-expectancy to benefit.
This trial will differ in three important aspects from the currently available literature and trials: 1) A prognostic score for overall survival (modified Mizumoto Score) will be used for selection of patients with favourable life expectancy [ 27], who are expected to benefit most from the intensified radiotherapy.
Life expectancy, time to benefit, functional status and medication related adverse events, polypharmacy, adherence to treatment are factors that need to be considered when forming appropriate guidelines for statin prescription in the very old.
These women, with long potential life expectancies, stand to benefit most from preventive measures and are the target population for chemopreventive agents [ 23].
Meanwhile, experts generally agree that a woman needs 5 to even 10 years of life expectancy to potentially benefit from mammography screening [ 1, 2].
Screening benefits depend on life expectancy and people with <5 10 years life expectancy are unlikely to benefit from screening, so it is still worthwhile considering the variability of life expectancy at different ages.
17 An innovative possibility is to apply the concept of 'pay-off time', predicting if a patient with limited life expectancy is likely to benefit from adherence to a particular guideline, by calculating the minimum time until its cumulative benefits exceed its cumulative harms.
Patient participation, because of its supposed effects on trust and patient expectancies, is assumed to benefit patients' recovery.
Surgery may be chosen if the patient is healthy enough and life expectancy is sufficiently long to benefit from pain relief, improved mobility, and care.
The lengthy natural history of some cases of DCIS implies that women with a limited life expectancy are less likely to benefit from treatment on a population level.
