By far most important is the characteristic "Emotional quality of life", followed by "Physical quality of life" and "Social quality of life" (on the same level in physicians; with some difference in patients) and the characteristics "Maximum increased life expectancy", "Long-term side-effects improbable" and "Flexibility of dosing" follow on rank 4 to 6.
As the trials are to be carried out in cancer patients with limited life expectancy, long-term repeat dose toxicology, genotoxicity and carcinogenicity studies may usually be omitted, but should be considered on a case by case basis.
Since most of the patients are going to be long-term survivors with high life expectancy, long-term sequelae (Strumberg et al, 2002), side effects and secondary morbidities (Hartmann et al, 1999, 2000), as well as psychosocial difficulties, sexual life problems and quality-of-life (QL) issues have become the major long-term complications of testicular cancer treatment.
When expressed as relative percentages of total life expectancy, a long life goes with a relatively long duration of cognitive impairment.
If life expectancy is long, prison health-care providers should be more aggressive in addressing slow-moving health threats; the long-term health needs of prisoners may be equally as important as short-term risk reduction.
My life expectancy is long.
Life expectancy has long been growing steadily for most Americans.
The stereotypical question about life expectancy – 'How long have I got?' – begs a simple, single-number answer.
In childhood cancer the survivor life expectancy is long and the impact of late sequelae on their life quality is high [ 1].
The benefits could persist even longer, and therefore tamoxifen is an attractive chemopreventive option, specifically in premenopausal women, where life expectancy is long.
Hence, ameliorating the late effects of radiotherapy would greatly improve the quality of life of the increasing number of cancer survivors, particularly in children where the remaining life expectancy is long.
