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SLE can start relatively early in life and results in impaired quality of life and shortened life expectancy because of a gradual disease progression leading to cardiovascular, renal and neoplastic disease.
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The most successful countries increased life expectancy not because of a general decrease in mortality at all ages, but because of a decrease in premature mortality.
For example, in my opinion, elderly women with a relatively short life expectancy because of comorbidity, with or without an increased risk for thromboembolic disease, would be better off on anastrozole than tamoxifen.
However, in adults with muscular dystrophy and a low life expectancy because of the natural course of the disease, CT might be a valuable alternative.
It is generally accepted that obesity leads to a reduced life expectancy because of these associated health problems.
5 Pipobroman and busulfan are second-line therapies reserved for patients with a shorter life expectancy because of their leukemogenic effect.
DPP-4 inhibitors are particularly indicated in young patients, with a long life expectancy, because of the protective effect on β-cell function.
However, glycemic goals might reasonably be relaxed in patients with long-standing type 1 diabetes and advanced complications or in those who are free of complications but have a limited life expectancy because of another disease process.
According to my model it's only 10-15 yeawayaway from where we'll be adding more than a year every year to life expectancy because of progress.
Chronic infection with cytomegalovirus leads to shorter life expectancy, mainly because of an increase in acute myocardial infarction.
"People in large cities have lower life expectancy because of pollution.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com