One of the reasons why antibodies have such good binding parameters is that in vivo they are subjected to rounds of expansion, selection and mutation which allow them to evolve with repeated exposure to the challenging agent.
Travis & Dytham [14] have recently produced a model that suggests that during range expansion selection may favour individuals with a higher propensity for dispersal.
Lower than expected polymorphism frequencies at synonymous sites may reflect demography (population expansion), selection at linked sites or purifying selection on the sites themselves.
The architecture of natural variation present in a contemporary population is a result of multiple population genetic forces, including population bottleneck and expansion, selection, drift, and admixture.
Harvest, isolation, activation, transduction, expansion, selection and cryopreservation of patient-derived T cells to produce bespoke medicinal therapies requires notable infrastructure and expertise.
In the GC, clonal expansion, selection and differentiation of GC B cells result in the production of high-affinity plasma cells and memory B cells that provide protection against subsequent infection.
The expansion selections were the highlight on the first day of a three-day convention in the Saddledome.
For example, population expansion, purifying selection or selective sweeps may result in an excess of rare variants [ 51, 52].
Evolutionary processes play an important role in shaping the dynamics of range expansions, and selection on dispersal propensity has been demonstrated to accelerate rates of advance.
It is possible that these large introns are recent recipients of extensive repetitive sequence expansions and selection has not had time to favor their reduction in size.
