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The five subtypes were compared by distribution of CTG expansion size, and the occurrence and onset of the main symptoms of DM1.
We failed to find any samples harboring the increased repeat expansion size.
ATXN3 pathogenic repeat expansion size was assessed in all samples using methods described previously by us [17].
What could be the mechanism for determining the expansion size of chromatophores in parallel with generation of chromatic pattern?
This result suggests that the expansion size of chromatophores oscillating at high frequency is determined by the synchrony of oscillatory behavior.
The expansion size of chromatophores oscillating at high frequency correlated with the number of synchronized chromatophores but not the oscillation frequency.
After more than 100 generations the expansion size remained unchanged indicating that the large expansions were stable in Drosophila (figure 1B).
The oscillatory system produces two kinds of motor output, chromatic pattern formation and expansion size of individual chromatophores, by controlling frequency and synchronization of the oscillatory behavior.
These results suggest that the basal expansion size is defined by the synchronized chromatophore number, not the oscillation frequency (Fig. 4).
BCAA levels were correlated with weight loss and, importantly, with disease progression and abnormal triplet repeat expansion size in the HD1 gene.
On the other hand, the chromatophores that oscillated at frequencies over 4 Hz showed a positive correlation between the expansion size and the synchronized chromatophore number (Fig. 4).
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