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Ex vivo expansion of primitive hematopoietic cells remains of interest for gene therapy and transplantation.
Decreased expression of these molecules may result in expansion of primitive tumorgenic cells by preventing differentiation.
Therefore, down-regulation of Spry1 favors the development and expansion of primitive hematopoietic cells from hemangioblast precursors.
Our previous studies on STAT5 downregulation also showed impaired maintenance and expansion of primitive human hematopoietic stem and progenitor cells [9], [10].
This indicates that abrogation of the inhibitory effect of Notch signaling in the niche may promote the expansion of primitive cells, thus facilitating evolution of prostate tumors.
The proliferative fetal phenotype may be replicated during the carcinogenic process resulting in the expansion of primitive cells by activating pathways that promote the self-renewal of FPSC.
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Thus, E2f, Nfy, Tead2 and Ap2 are likely to be involved in the self-renewal and expansion of the primitive prostate population.
Expansion of the primitive distal Hoxd domain by sustained signaling from the AER is consistent with Thorogood's proposal that the extent of endoskeletal development in actinopterygian and sarcopterygian appendages is controlled by the timing of the transition of the AER to an AEF [25].
Thus, this approach allows for highly reproducible expansion of very primitive hematopoietic cells.
The formation of the so-called "foreland basin" [ 74] may have permitted the rapid expansion of a primitive Bryconidae throughout the proto-Paraná and proto-Amazon system.
Also, mutation of Ectodermin, an intracellular inhibitor of Nodal signalling, causes an expansion of the anterior primitive streak [45].
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