According to this hypothesis, cancer cannot be viewed as simple monoclonal expansions of functionally equal tumor cells.
According to this model, cancer cannot be viewed as simple monoclonal expansions of functionally equal tumour cells.
More importantly, the antigen-specific CD8+ T cells, which were detected at B6 with the concomitant expansion of Tregs, were functionally active and actively released IFN-γ upon antigenic stimulation (Fig. 4b).
Lineage-specific expansions and gene loss events detected as the result of comparative analysis of the domain compositions of different proteomes have been examined mostly at a qualitative level, in terms of the underlying biological phenomena, such as adaptation associated with expansion or coordinated loss of functionally linked sets of genes [ 15].
NK cell lymphocytosis in these patients results from an aberrant expansion of an immature and functionally deficient NK cell population [ 32].
To determine the optimal expansion strategy for obtaining high numbers of functionally active human alloantigen-specific Treg from CD4posCD25high Treg, we devised four different strategies, consisting of two subsequent cycles of expansion with alternated polyclonal and alloantigen-specific stimulation (Figure 1).
Lee, G. Q. et al. Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells.
With the objective to obtain the highest numbers of functionally active Treg with optimal direct alloantigen-specificity, we devised four expansion strategies, employing polyclonal and alloantigen-specific stimulation in two subsequent cycles of Treg expansion (Figure 1).
In fact, a massive expansion of the calpain family occurred by domain shuffling among unicellular eukaryotes and contributed to a wealth of functionally different genes.
A comparative study of functionally graded versus a homogeneous sandwich core is presented by considering the first term of the expansion as the loading condition.
Our findings strongly support expansion of genomic resources and analyses of the functionally differentiated silk gland types, other tissues of interest, as well as into other spider species.
