These results indicate that delivery of OVA to DEC-205+ DCs in the presence of CD40 ligation induces expansion of tetramer binding memory CD8+ T cells in both spleen and liver, and that these T cells respond rapidly to antigen rechallenge.
RACK1 also functions as a homodimer enabling the expansion of its binding partners [ 28, 29, 49, 53, 54].
It is possible, however, that primate lineages that we have not yet studied have indeed been subject to repeat-driven expansion of CTCF binding, as other primate SINEs such as Alu elements have been active recently.
Building on the ZFN work, this new DNA-binding platfacilitatedtheed the rapid expansion of DNA-binding proteins using novel TAL DNA-binding domains.
Finally, we provide compelling evidence that the same process that currently drives lineage-specific expansion of CTCF-binding events in diverse mammals ancestrally generated the core set of strong, deeply conserved CTCF-binding events.
In contrast to the expansion of Duffy-binding domains in P. falciparum, the expansion of PAN and EGF domains appears to be coccidian specific.
Thus, this model provides an opportunity to study the molecular mechanisms that promote the expansion of placenta-binding parasites also observed in human PAM.
P. falciparum is also known to exhibit an expansion of Duffy-binding domains [57], which are much less common in other Plasmodium spp. and restricted to this genus [58].
Simple expansion of peptide-binding hydrophobic regions on our Spy variants could thus be one straightforward way to explain their improved chaperone activity.
The expansion of CTCF-binding events numbers in the hundreds, and the CTCF-bound MIR elements in opossum contain only M1 motifs, with no evidence of associated M2 motifs.
The expansion of motif-binding domains linking compact and degenerate peptides to important functions greatly increased the information processing potential of the cell by simplifying access to regulatory pathways and cell state information.
