Sentence examples for expansion of a codon from inspiring English sources

Such relaxed selection may then permit invasion and expansion of a codon repeat.

Contraction or expansion of a codon repeat in a transcription factor has the potential to modulate gene regulation in a quantitative, rather than qualitative, manner [ 10, 30] and, therefore, result in a mutation of small effect [ 22].

Polyglutamine (polyQ) diseases are inherited neurodegenerative disorders caused by the expansion of CAG codon repeats, which code for polyQ in the corresponding gene products.

Polyglutamine (polyQ) diseases are caused by the expansion of CAG codon repeats resulting in extended polyQ tracts in the expressed proteins [1].

Several neurodegenerative diseases including Huntington's disease and a variety of spinocerebellar ataxias are caused by a pathogenic expansion of CAG codons in disease genes leading to the production of proteins with elongated polyglutamine (polyQ) tracts.

We denote the frequency of a codon or a group of codons with a superscript for the codon's phase and a subscript for the codon.

The expansion of codons encoding such amino acids might be better tolerated than the expansion of hydrophobic amino acid stretches because they probably would not change the three-dimensional protein conformation as drastically.

However, diseases attributed to trinucleotide repeat expansion have runs of a single codon (polyglutamine; reviewed in [ 31]) and not a varying repeat unit, as seen with ELN.

The best-known example for disease-causing trinucleotide expansions is Chorea Huntington, a disease provoked by extensive expansions of CAG codons in the first exon of the gene for huntingtin resulting in stretches of up to 200 Gln residues [5].

This finding is consistent with Katti et al. [ 76] who showed that expansions of codon repeats corresponding to small hydrophilic amino acids are tolerated more, while strong selection pressures probably eliminate codon repeats encoding for hydrophobic and basic amino acids.

Besides expansions of Gln codons, extensions of Ala segments occur as well and can lead to diseases and/or developmental disorders [6], [7].